The residue was recrystallized from etoachexane to give 0. It also contains a complete crossindex into the chemicals of the second half. The phosphoric acid ester of 4hodet is known as 4 phosphoryloxy det, cey19, or ethocybin history. The subject of the work is psychoactive phenethylamine chemical derivatives, notably those that act as psychedelics andor empathogenentactogens. The main title is an acronym that stands for phenethylamines i have known and loved. The solid residue was recrystallized from meohet2o to give 0. Det, also known under its chemical name n,ndiethyltryptamine and as t9, is a psychedelic drug closely related to dmt and 4 ho det. Tihkal is an acronym that stands for tryptamines i have known and loved. In it he writes that he truly doubts that there is another psychedelic drug, anywhere, that can match this one for speed, for intensity, for brevity, and sensitive to dose, at least one that is active orally. To 10 ml of a stirred solution of lah 1 m in thf under n 2, there was added dropwise a solution of 0. The first half of tihkal is an excellent commentary on the shulgins personal experiences with tryptamines. It is the 4 hydroxyl analog of dipropyltryptamine dpt.
Very little data exists about the pharmacological properties. Tihkal tryptamines i have known and loved is the continuation of the shulgins earlier book, pihkal phenethylamines i have known and loved. The substance was used together with its phosphoryloxyanalog ethocybin in human clinical trials in the. The continuation is a 1997 book written by alexander shulgin and ann shulgin about a family of psychoactive drugs known as tryptamines. This was treated with a 40% solution of methyl isopropylamine in dry et 2 o. The phosphate ester, psilocybin, requires two additional steps. It was first synthesized by albert hoffman, the discoverer of lsd. A visual index and map of tihkal, including the formatted text of book ii. It was first made by alexander shulgin and is mentioned in his book tihkal, but was never tested by him. The acetic acid ester of 4hodet is known as 4 aco det. Repke in 1977, its effects in humans were investigated by alexander shulgin. The chemistry continues by alexander and ann shulgin. Alexander shulgin and ann shulgin which was published in 1991.
The reaction mixture was stirred for an additional 30 min, and the yellow crystalline solid was removed by filtration and dissolved in 10 ml of anhydrous thf. Shulgins trials and other anecdotal information suggest that 4homipt is a synthetic psychedelic similar in activity to psilocin. One equivalent of dilute hcl was added, and the volatiles were removed under vacuum. Following the publication of its synthesis by david b. This was added dropwise at a rate that maintained the reaction at reflux. Please at least give me a reason why i never got my order its been 2 full months ive emailed several times and have gotten no response and it didnt get seized i have already ordered twice from amsterdam and received both orders and those orders were made a month after i made my first order with you guys so theres an issue and its not with shipping its with orders never even being sent as.
It was synthesized by the noted chemist alexander shulgin and described in his book, tihkal tryptamines i have known and loved. After inventing lsd hoffman extracted psilocin, psilocybin, and baeocystine from psilocybe cubensis and started tweaking the psilocin molecule to see what he could come up with. When the addition was complete, the reflux was maintained for an additional 15 min and then the reaction was. When the addition was complete, the reaction mixture was brought to a reflux for 15 min. Shulgin reported a dosage of 20mg orally to be without effects.
When the addition was complete, the reflux was maintained for an additional 15 min and then the. In his book tihkal, neither the minimum dosage nor the duration are reported. In his book tihkal tryptamines i have known and loved, the dosage is listed as 1020 mg. The residue was distilled at the kugelrohr and the distillate dissolved in 1 ml meoh. The residue was distilled in a kugelrohr apparatus and the solid distillate recrystallized from etoachexane to give 0.
It is the 4 hydroxy analog of dipt and is structurally related to tryptamines like 4 ho dmt psilocin, 4 ho mipt miprocin, and 4 ho det ethocin. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at r 3 to an amino group via an ethyl side chain. A chemical love story, tihkal is an acronym that stands for tryptamines i have known and loved. However, despite its structural similarity to dmt, its activity is induced by an oral dose of around 50100 mg, without the aid of mao inhibitors, and the effects last for about 2 4. It is found either as its crystalline hydrochloride salt or as an oily or crystalline base. To 8 ml of a stirred solution of lah 1 m in thf under n 2, there was added dropwise a solution of 0. There was then added an excess of 2n hcl, the mixture cooled, and the resulting solids removed by filtration. The reaction mixture was stirred for an additional 30 min, and the intermediate indoleglyoxyl chloride separated as a yellow crystalline solid but was not isolated. Lets get right to it these books are about drugs and their potential positive uses.